Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing

Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing

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Finally, we described a sex-induced silencing (SIS) phenomenon in C. neoformans. Using genetic approaches, we showed that SIS is triggered by a tandem insertion of a transgene during the sexual cycle. Interestingly, only a proportion of progeny carrying the transgene are silenced. Gene deletion, RIP, or DNA methylation do not contribute to SIS but the RNAi machinery is required. In conclusion, these studies provide further understanding of sex in C. neoformans from different perspectives, which invites comparisons to other fungal and even more broadly, eukaryotic pathogens to address the role of sex in evolution.Joseph Heitman, MD, PhD, Supervisor. Daniel Lew, PhD. Hiroaki Matsunami, PhD. Thomas Petes, PhD. Robin Wharton, PhD An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophyanbsp;...


Title:Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
Author:
Publisher:ProQuest - 2008
ISBN-13:

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